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Berberine activates adenosine monophosphate kinase (AMPK). \u003ca href=\"http:\/\/www.integrativepro.com\/Resources\/Integrative-Blog\/2015\/AMPK-Activation\" target=\"_blank\" rel=\"noopener noreferrer\"\u003eAMPK is activated through various mechanisms\u003c\/a\u003e including exercise to support glucose metabolism via an insulin-independent mechanism. Berberine has been the subject of human, randomized placebo-controlled trials.The formula supports the healthy balance of bacteria in the digestive tract, which also supports the immune system.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBlood sugar metabolism and insulin metabolism\u003c\/li\u003e\n\u003cli\u003eMetabolic function\u003c\/li\u003e\n\u003cli\u003eCardiovascular function and lipid metabolism\u003c\/li\u003e\n\u003cli\u003eInsulin receptor expression, with direct impact on supporting healthy glucose metabolism\u003c\/li\u003e\n\u003cli\u003eRegulation of glycation\u003c\/li\u003e\n\u003cli\u003eSupports immunity and gastrointestinal health by balancing intestinal flora\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eGluten Free\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eScience Backed\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eProfessional Strength Formula\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e"}