{"id":9171027722492,"title":"THER-BIOTIC TARGET GB-X","handle":"ther-biotic-target-gb-x","description":"\u003cp\u003eTarget gb-X™ is a probiotic supplement specifically designed to support positive mood by influencing the gut-brain axis through the microbiome. It is powered by Ecologic BARRIER, a 5B CFU blend of 9 probiotic strains, that has been clinically shown to decrease overall cognitive reactivity to sad mood, rumination, negative thoughts, and aggressive thoughts.\u003csup\u003e1\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eHeightened cognitive reactivity to sad mood is an established risk factor for more serious mood alterations in otherwise healthy individuals and is therefore considered an important target for interventions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTarget gb-X™ Mechanism \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTarget gb-X™ with Ecologic BARRIER was specifically designed to influence the gut-brain axis through defined mechanisms including strengthening of the gut barrier function, modulation of cytokines and inflammatory response, production of potentially neuroprotective metabolites, and HPA regulation. Preclinical research emphasized a pronounced shift away from macrophage-produced cytokines to T-lymphocyte-produced cytokines, a reduction in circulating lipopolysaccharide endotoxins, and a marked reduction in transcription of hippocampal genes related to HPA regulation.\u003csup\u003e2\u003c\/sup\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProbiotics and the Gut-Brain Axis \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe gut-brain axis refers to the bidirectional communication network between the central and autonomic nervous systems and the intestines. Gut-brain communications are mediated by the immune system, endocrine connections such as the hypothalamic-pituitary-adrenal (HPA) axis, and neural pathways involving the enteric nervous system. The gut microbiota is now known to play a pivotal role in gut-brain communications. It is a complex interaction whereas the microbiota engages locally with intestinal cells as well as communicating directly with the central nervous system through neuroendocrine, immune, and metabolic pathways.\u003csup\u003e3\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eResearch into gut-brain mechanisms is rapidly expanding our understanding and serves to inform the development of targeted probiotic formulations\u003c\/p\u003e","published_at":"2025-11-18T14:45:12-05:00","created_at":"2025-11-18T14:45:12-05:00","vendor":"Klaire Labs","type":"","tags":["Brand_Klaire Labs","Dietary Restrictions_Dairy Free","Dietary Restrictions_Gluten Free","Dietary Restrictions_Nut Free","Dietary Restrictions_Paleo","Dietary Restrictions_Soy Free","Dietary Restrictions_Vegan","Price_$25 to $50","Product Type_Capsules"],"price":4599,"price_min":4599,"price_max":24904,"available":true,"price_varies":true,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":48510466883836,"title":"Single Unit","option1":"Single Unit","option2":null,"option3":null,"sku":"6595","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"THER-BIOTIC TARGET GB-X - Single Unit","public_title":"Single Unit","options":["Single Unit"],"price":4599,"weight":68,"compare_at_price":null,"inventory_management":"shopify","barcode":"790616310081","requires_selling_plan":false,"selling_plan_allocations":[]},{"id":48510466916604,"title":"3 Pack","option1":"3 Pack","option2":null,"option3":null,"sku":null,"requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"THER-BIOTIC TARGET GB-X - 3 Pack","public_title":"3 Pack","options":["3 Pack"],"price":13107,"weight":204,"compare_at_price":null,"inventory_management":null,"barcode":"790616310081","requires_selling_plan":false,"selling_plan_allocations":[]},{"id":48510466949372,"title":"6 Pack","option1":"6 Pack","option2":null,"option3":null,"sku":null,"requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"THER-BIOTIC TARGET GB-X - 6 Pack","public_title":"6 Pack","options":["6 Pack"],"price":24904,"weight":408,"compare_at_price":null,"inventory_management":null,"barcode":"790616310081","requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/www.progressivenutracare.com\/cdn\/shop\/files\/FRONT_0220298a-632b-4cd2-8b47-36d790dbd4ee.png?v=1763496009","\/\/www.progressivenutracare.com\/cdn\/shop\/files\/PANEL_8045cd47-4950-4b43-b8bd-e5cd92e01fa4.png?v=1763496009"],"featured_image":"\/\/www.progressivenutracare.com\/cdn\/shop\/files\/FRONT_0220298a-632b-4cd2-8b47-36d790dbd4ee.png?v=1763496009","options":["QUANTITY"],"media":[{"alt":null,"id":37995287806204,"position":1,"preview_image":{"aspect_ratio":1.0,"height":470,"width":470,"src":"\/\/www.progressivenutracare.com\/cdn\/shop\/files\/FRONT_0220298a-632b-4cd2-8b47-36d790dbd4ee.png?v=1763496009"},"aspect_ratio":1.0,"height":470,"media_type":"image","src":"\/\/www.progressivenutracare.com\/cdn\/shop\/files\/FRONT_0220298a-632b-4cd2-8b47-36d790dbd4ee.png?v=1763496009","width":470},{"alt":null,"id":37995287838972,"position":2,"preview_image":{"aspect_ratio":1.006,"height":688,"width":692,"src":"\/\/www.progressivenutracare.com\/cdn\/shop\/files\/PANEL_8045cd47-4950-4b43-b8bd-e5cd92e01fa4.png?v=1763496009"},"aspect_ratio":1.006,"height":688,"media_type":"image","src":"\/\/www.progressivenutracare.com\/cdn\/shop\/files\/PANEL_8045cd47-4950-4b43-b8bd-e5cd92e01fa4.png?v=1763496009","width":692}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003cp\u003eTarget gb-X™ is a probiotic supplement specifically designed to support positive mood by influencing the gut-brain axis through the microbiome. It is powered by Ecologic BARRIER, a 5B CFU blend of 9 probiotic strains, that has been clinically shown to decrease overall cognitive reactivity to sad mood, rumination, negative thoughts, and aggressive thoughts.\u003csup\u003e1\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eHeightened cognitive reactivity to sad mood is an established risk factor for more serious mood alterations in otherwise healthy individuals and is therefore considered an important target for interventions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTarget gb-X™ Mechanism \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTarget gb-X™ with Ecologic BARRIER was specifically designed to influence the gut-brain axis through defined mechanisms including strengthening of the gut barrier function, modulation of cytokines and inflammatory response, production of potentially neuroprotective metabolites, and HPA regulation. Preclinical research emphasized a pronounced shift away from macrophage-produced cytokines to T-lymphocyte-produced cytokines, a reduction in circulating lipopolysaccharide endotoxins, and a marked reduction in transcription of hippocampal genes related to HPA regulation.\u003csup\u003e2\u003c\/sup\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProbiotics and the Gut-Brain Axis \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe gut-brain axis refers to the bidirectional communication network between the central and autonomic nervous systems and the intestines. Gut-brain communications are mediated by the immune system, endocrine connections such as the hypothalamic-pituitary-adrenal (HPA) axis, and neural pathways involving the enteric nervous system. The gut microbiota is now known to play a pivotal role in gut-brain communications. It is a complex interaction whereas the microbiota engages locally with intestinal cells as well as communicating directly with the central nervous system through neuroendocrine, immune, and metabolic pathways.\u003csup\u003e3\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eResearch into gut-brain mechanisms is rapidly expanding our understanding and serves to inform the development of targeted probiotic formulations\u003c\/p\u003e"}